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KMID : 1007520140230020593
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Food Science and Biotechnology
2014 Volume.23 No. 2 p.593 ~ p.599
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Effect of Oral Administration of Fucosterol from Hizikia fusiformis on DNCB-induced Atopic Dermatitis in NC/Nga Mice
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Hwang Eun-Son
Park Sang-Yong
Shin Heon-Sub
Lee Don-Gil
Yi Tae-Hoo
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Abstract
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Fucosterol was extracted and purified from the brown algae Hizikia fusiformis. We assessed the antiinflammatory effects of fucosterol on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like lesions in NC/Nga mice. Fucosterol decreased the lipopolysaccharideinduced production of nitric oxide in mouse macrophage cells. Oral administration of fucosterol (200 mg/kg weight/ day) decreased the frequency of scratching, epidermal thickness of the dorsal skin, and number of degranulated mast cells. In addition, fucosterol treatment decreased levels of DNCB-stimulated serum immunoglobulin E (IgE). Compared to the control concanavalin A, fucosterol inhibited levels of IL-4 and TNF-α and increased secretion of IFN-γ, in the media of cultured splenocytes. Taken together, our results suggest that fucosterol may attenuate AD-like lesions by exerting anti-inflammatory effects, including inhibition of IgE and inflammatory cytokines, which modulate the Th1/Th2 balance.
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KEYWORD
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fucosterol, atopic dermatitis, immunoglobulin E, IFN-γ, IL-4
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